The emerging field of lipidomics has identified lipids as key players in disease physiology. Their physicochemical diversity allows precise control of cell structure and signaling events through modulation of membrane properties and trafficking of proteins. As such, lipids are important regulators of brain function and have been implicated in neurodegenerative and mood disorders. Importantly, environmental chronic stress has been associated with anxiety and depression and its exposure in rodents has been extensively used as a model to study these diseases. With (...) the accessibility to modern mass‐spectrometry lipidomic platforms, it is now possible to snapshot the extensively interconnected lipid network. Here, we review the fundamentals of lipid biology and outline a framework for the interpretation of lipidomic studies as a new approach to study brain pathophysiology. Thus, lipid profiling provides an exciting avenue for the identification of disease signatures with important implications for diagnosis and treatment of mood disorders. (shrink)

Este relato de experiência traz quatro depoimentos de três alunos/a e um professor do programa de pós-graduação stricto sensu em Ensino de História da África do Instituto Superior de Ciências de Educação, situado no sudoeste angolano. Pretende-se acompanhar as trajetórias pessoais destes pesquisadores em torno do ensino e pesquisa em história da África, tanto em Angola quanto no Brasil.

Deep brain stimulation is part of state-of-the-art treatment for medically refractory Parkinson’s disease, essential tremor or primary dystonia. However, there are multiple movement disorders that present after a static brain lesion and that are frequently refractory to medical treatment. Using Holmes tremor as an example, we discuss the effectiveness of currently available treatments and, performing simulations using a Markov Chain approach, propose that DBS with iterative parameter optimization is expected to be more effective than an approach based on sequential trials (...) of pharmacological agents. Since, in DBS studies for HT, the thalamus is a frequently chosen target, using data from previous studies of lesion connectivity mapping in HT, we compared the connectivity of thalamic and non-thalamic targets with a proxy of the HT network, and found a significantly higher connectivity of thalamic DBS targets in HT. The understanding of brain networks provided by analysis of functional connectivity may thus provide an informed framework for proper surgical targeting of individual patients. Based on these findings, we argue that there is an ethical imperative to at least consider surgical options in patients with uncommon movement disorders, while simultaneously providing consistent information regarding the expected effectiveness and risks, even in a scenario of surgical-risk aversion. An approach based on n-of-1 DBS trials may ultimately significantly improve outcomes while informing on optimal therapeutic targets and parameter settings for HT and other disabling and rare movement disorders. (shrink)

O que o leitor encontrará neste volume são 25 primorosos testemunhos do percurso que a Associação Brasileira de Linguística, a Abralin, percorreu nesses 50 anos, tendo, como pano de fundo, a criação no país dos cursos especializados de graduação e pós-graduação em Linguística; a emergência de novos temas e novas metodologias de pesquisa; as inovações tecnológicas; a atuação política das associações científicas como lugar de resistência democrática e o seu papel na busca do conhecimento e do bem do homem. Vale (...) a pena perseguir pelos textos este fio condutor, correlacionando-o com os temas colocados em evidência nas conferências e mesas-redondas pelas respectivas Diretorias. Os textos que compõem o presente volume revivem, pois, a construção da grandeza da Abralin e, por tabela, do desenvolvimento da Linguística no Brasil, enquanto disciplina autônoma de ensino e pesquisa. Estão aqui registradas, quase todas em primeira pessoa, contribuições inestimáveis. (shrink)

Com este artigo, problematizou-se o potencial da formação continuada de professores por meio da educação a distância mediada pelo Moodle. Nessa perspectiva, pesquisou-se, principalmente, a integração hipermidiática das tecnologias nesse ambiente virtual de aprendizagem, no curso a distância de pós-graduação lato sensu em Mídias na Educação. Para isso, selecionou-se uma aula de uma disciplina desse curso oferecida no primeiro semestre de 2011 por uma universidade na qual um dos autores deste artigo trabalhou como professor-tutor. Assim, foi realizada uma investigação com (...) base na abordagem metodológica qualitativa através da observação participante, na qual se percebeu que a integração da hipermídia potencializa o diálogo-problematizador, a interatividade e o desenvolvimento da flexibilidade cognitiva nos professores-cursistas. Dessa forma, observou-se que a navegação em uma hipermídia educacional respeita o ritmo e as maneiras de aprendizagem de cada sujeito, uma vez que possibilita que os temas a serem estudados sejam acessados de forma não-linear, ou seja, de acordo com o interesse de cada aprendente e por meio de diferentes mídias. Isso viabilizou aos cursistas fazerem diversas associações entre diferentes conteúdos inter-relacionados, proporcionando assim uma ampliação da visão sobre os assuntos educacionais abordados na disciplina e, posteriormente, poderem aplicar esse conhecimento em novas situações de ensinoaprendizagem. (shrink)

Ultimamente bastante atençáo vem sendo dispensada ao estudo do ceticismo moderado na modernidade. O famoso historiador da filosofia Richard Popkin, em sua História do Ceticismo de Erasmo a Espinosa , cunhou a denominaçáo de ceticismo epistemológico para qualificar os membros desta corrente e nela inseriu os filósofos setecentistas Gassendi e Mersenne, considerando-os seus principais representantes. Além disso, no século XVIII temos o denominado ceticismo mitigado de Hume, que chamou a atençáo dos filósofos modernos para definir os limites do ceticismo. Este (...) artigo procura contribuir para o estudo do ceticismo moderado na modernidade, mostrando náo só que Hume, Mersenne e Gassendi podem fazer parte do assim chamado ceticismo epistemológico ou mitigado, mas também que há certos elementos comuns em suas filosofias destinados a mitigar os argumentos dos céticos de seu tempo. (shrink)

O pensamento de Hume pode ser comparado ao dos céticos modernos em muitos aspectos. Com relação ao tópico da racionalidade dos animais, Hume parece seguir de perto a leitura de alguns céticos modernos e se afastar consideravelmente da de Descartes. Por outro lado, diferente de filósofos como Montaigne, Charron e La Mothe Le Vayer, Hume não tinha por finalidade colocar a racionalidade humana num nível próximo dos animais para apenas provar a fraqueza do intelecto diante do desconhecido, mas intentava comparar (...) o nosso modo de proceder ao do animal para avaliar, com mais precisão, as suas teorias acerca da natureza humana. Neste artigo analiso o modo como os primeiros céticos da modernidade trataram da questão da razão dos animais e o comparo com as ideias de Hume sobre o assunto, sem deixar de mencionar as contribuições de Descartes e de Pierre Bayle. (shrink)

The topic of spirituality is gaining an increasing visibility in organizational studies. It is the authors contention that every theory of organization has explicit or implicit views of spirituality in the workplace. To analyze the presence of spiritual ideologies in management theories, they depart from Barley and Kunda's Administrative Science Quarterly article and analyze management theories as spirituality theories with regard to representations of people and the organization. From this analysis, we extract two major dimensions of people (as dependent or (...) independent workers) and the organization (as spiritually informed or spiritually uninformed) that, in combination, result in a typology that advances four organizational types of spirituality: the soulful organization, the holistic organization, the ascetic organization, and the professional organization. The expression of spirituality in each of these forms is discussed with the aim of contributing to a critically informed analysis of organizational spirituality. (shrink)

El presente trabajo tiene como objetivo elucidar en qué sentido la idea de acontecimiento está presente en la filosofía de Michel Foucault, más como operador práctico en el modo de investigación que como puro concepto teórico. Pasando puntualmente por algunos trabajos reunidos en la obra Dits et Écrits, se intenta mostrar la real aparición de tal concepto a través de la aproximación del filósofo con la historia, en la elucidación de las relaciones entre el saber y el poder. Los ejemplos (...) clásicos de investigación sirvieron de base para establecer la relación entre el acontecimiento y la práctica filosófica que le es característica. (shrink)

A fibromialgia é uma síndrome crônica, não inflamatória caracterizada por dores musculoesqueléticas difusas e pela presença de pontos dolorosos em determinadas regiões do corpo "Tender Points". Seu diagnóstico é clínico, não havendo alterações laboratoriais específicas. O enfoque deste trabalho é co..

Background: Psychedelics are known for their powerful mental effects due to the activation of 5HT-2A receptors in the brain. During the 1950s and 1960s, research was conducted on these molecules until their criminalization. However, their clinical investigation as therapeutic tools for psychiatric disorders has revived the deontological ethics surrounding this subject. Questions arise as research on their therapeutic outcome becomes a reality. We aim to explore deontological ethics to understand the implications of psychedelics for the clinician, patient, and society. Results: (...) A total of 42 articles were considered for this review. Methods: A methodological search of psychedelic studies from 2017 to 2022 was conducted in PubMed, Scopus, EBSCOhost, and ScienceDirect to address the deontological ethics of clinical psychedelic use. Conclusion: Psychedelics need to be culturally contextualized, epistemic harm minimized and represented to ensure informed consent. Open data and commissions are needed to ensure safe and equal distribution. (shrink)

The aim of this study was to examine the influence of somatic maturation in anthropometric, physical, and game-related variables in youth basketball age groups under-13 and under-15. One-hundred and eighty-five basketball players performed anthropometrical and physical tests during a non-official youth basketball tournament. Predicted maturity offset and game-related variables were also analyzed. Cluster analysis was used to analyze the between-maturation status differences in all parameters in each age group. Also, regularized generalized canonical correlation analysis was used to assess relative contributions (...) of maturational, physical, and game-related variables within each age group. Based on MO, two different clusters were identified within each age category. Greater differences in MO were identified among U-13 clusters than among U-15 clusters. No significant differences were observed between clusters in terms of physical and game-related variables. High correlations between maturational, physical, and game-related variables were found for boys. In girls, different trends in terms of correlations were observed. The strongest association between blocks was observed between physical tests and game-related variables in all age categories, except for U-15 girls. Knowing and identifying performance profiles according to biological age is of upmost importance since it allows the coach to create challenging situations adjusted to the individual’s needs. (shrink)

Richard Popkin, no capítulo VII de sua “História do ceticismo de Erasmo a Spinoza”, apresenta uma tendência predominante na filosofia moderna de rejeitar o ceticismo pirrônico, por ser demasiado destrutivo, e o dogmatismo extremo, por ser questionável. A solução para esses partidários foi a de adotar um ceticismo que Popkin denomina mitigado ou construtivo, isto é, uma teoria que reconheça a impossibilidade de alcançarmos as verdades absolutas acerca da natureza e realidade, mas que admita a possibilidade de um certo conhecimento, (...) que possa ser convincente e provável, embora não metafisicamente inquestionável. Esta espécie de dúvida filosófica ganhou força com o advento da filosofia cartesiana, mas só tornou-se definitivamente respeitável com a sua formulação por David Hume, sustenta ainda Popkin. Neste trabalho mostraremos que os filósofos Pierre-Daniel Huet e Simon Foucher, além de Hume, poderiam entrar nesta categoria, que também pode ser definida de ceticismo acadêmico. (shrink)

Aim: To analyze the empathizing and systemizing profiles of Brazilian and Portuguese nursing undergraduates. Background: Empathy is a fundamental skill for nursing practice and should be analyzed during the student’s education. Methods: Descriptive study with cross-sectional design. Participants were 968 undergraduate students, including 215 (22.2%) Brazilians from a university in the state of São Paulo and 753 (77.8%) Portuguese students from a higher education institution in central Portugal. The Portuguese and Brazilian versions of the Empathizing/Systemizing Quotient have good internal consistency (...) and reliability. Ethical considerations: In Brazil, approval for the study was obtained from the Research Ethics Committee of the University of São Paulo at Ribeirão Preto College of Nursing (protocol 191/2016) and in Portugal, from the Ethics Committee of the Health Sciences Research Unit: Nursing, Coimbra Higher School of Nursing (protocol P362-09/2016). Results: Most (86%) participants were female and aged between 20 and 24 years. In the general profile analysis between both groups, the domains “Social Skills,” “Contents,” and “Processes” scored higher. Gender differences exist for the feeling of empathy and systemizing, as women scored better on the short version of the Empathy Quotient and men on the Systemizing Quotient. Conclusion: As demonstrated in the domain scores for “Social Skills,” “Contents,” and “Processes,” the undergraduate nursing students analyzed have the ability to deal intuitively and spontaneously with social situations; they are also characterized as methodical people, who like to follow rules, and experience practice better than theory, and the women have a higher empathetic level than men, who in turn are more systemizing. (shrink)

Most of the contributions collected in this volume are revised versions or alternative discussions of the papers presented in June-July 2017 at the Department of Philosophy from the University of Bergen/ Norway, in the context of the workshop Wittgenstein in/on translation, held under the auspices of the Strategic Programme for International Research and Education (SPIRE). Natasha Gruver and Miguel Quesada Pacheco were also invited, but their contributions could not be delivered at that time, for different reasons. We are glad (...) to include them here, as well as a completely new one from Rafael Azize, who has always kept a close dialogue with the Brazilian guests that came to Bergen. Interestling, all these three additional texts deal somehow with endeavors that have, to some extent, the character of an experiment – be it like a pure Wittgen- steinian thought experiment or its application to pragmatic or expressivepraxis. The purpose of the meeting was to discuss existing and new approaches to the theory and practice of translating Wittgenstein and philosophy. Wittgenstein is one of the most profound thinkers about language; his Nachlass includes a substantial corpus of his own translations of his writings from German to English or English to German, as also comments and corrections to translations by others of his own writings. Taking this into account, part of the expected results of the project is the production of exemplary studies of the subject, e.g., using Wittgenstein's own translations or own revisions of translations of his works: Wittgenstein on translation. A complementary line is to look at how his work has been or can be rendered into other languages (or research areas): Wittgenstein in translation. This task can be accomplished through a general overview involving several languages, or looking at special cases. The project took both perspectives into account. Special cases that received a closer look are, on the one hand, English as the most translated into language, notably in connection with Wittgenstein‟s own revisions of his work; on the other hand, already existing translations into Portuguese and a pro-ject produced Amerindian translation of Wittgenstein. (shrink)

Dias de Nietzsche em Turim de Bressane / Dias / Miguel Angel de Barrenechea -- A atopia potente de Antonio das Mortes: pensamento original e perspectiva histórica / Rodrigo Guéron -- Dioniso é Brasileiro? / Selda Engelman -- Theatrum Mundi: Filosofia e canção / Olgária Chaim Matos -- Uma filosofia do amor em Cartola / Rosa Dias -- Música e diferença: uma crítica à escuta "desinteressada" do cotidiano / Samuel Araújo -- As estruturas dualísticas dos cantos ritualísticos dos Índios (...) Karajá: um reflexão sob a ótica filosófica de fundamentação nietzchiana / Suely Brígido -- Choque de intensidade na ética / Luiz B.L. Orlandi -- Por um filosofia artístico-rizomática da leitura / Daniel Lins -- Nietzsche, a negatividade e a antropofagia: do Cordeiro e da Ave da Rapina ao Jabuti / Maria Cristina Franco Ferraz -- Entre o teatro e a loucura: uma experiência de "esquizocenia" / Peter Pál Pelbart --. (shrink)

1 This paper has been presented at the workshop “Time and Modality: A Round Table on Tense, Mood, and Modality”, Paris, December 2005, at a CUNY linguistics colloquium in May 2006, and at the 6th Workshop on Formal Linguistics in Florian´opolis, Brazil, August 2006. We thank the audiences at those presentations, in particular Orin Percus, Tim Stowell, Marcel den Dikken, Anna Szabolcsi, Chris Warnasch, Roberta Pires de Oliveira, Renato Miguel Basso, and Ana M¨uller. We thank Noam Chomsky, Cleo (...) Condoravdi, and Irene Heim for very helpful conversations about this material. We thank Bridget Copley for sharing with us her recent manuscript “What Should Should.. (shrink)

A proposta do texto é delinear como Heráclito e Platão lidaram com o problema de usar a linguagem para falar do movimento. A perspectiva ontológica de que eles partem é quase oposta. Heráclito vê o mundo como movimento contínuo enquanto, para Platão, o que está em movimento participa, em alguma medida, das Ideias estáticas. É deste ponto de vista que no Teeteto Sócrates encarrega os Heraclitianos de criarem um novo discurso caso queiram falar da sua concepção de mundo. A observação (...) tem um tom crítico, mas não parece estar muito errada se consultarmos os fragmentos do pré-socrático. Em B1 Heráclito declara discorrer segundo a natureza. Utilizando isso como justificativa tomo B67 como um paradigma de como o Efésio repete a ordem do mundo na ordenação dos seus discursos. A primeira palavra, deus, seria o unificador, enquanto os pares de opostos subsequentes citados sem uso de conectivos demonstrariam esta união. Uma vez construída esta concepção retorno ao Teeteto onde Platão oferece outra estratégia de uso da língua para falar do movimento. Ao contrário de Heráclito, ele recorre aos sincategoremas para unir os opostos. Um mobilista deveria falar que algo é 'assim' e 'não assim' mostrando, desta maneira, o estatuto ambíguo das coisas. Como este estatuto não é reconhecido por Platão trata-se de uma crítica à ontologia mobilista. O passo final é ver como Platão usa a linguagem para falar da sua ontologia particular. O discurso usado para se referir às Ideias repete a estratégia de recorrer aos sincategoremas uma vez que a Ideia de algo é dita ser algo 'em si'. A conclusão é que enquanto Heráclito tenta suprimir sua linguagem das palavras que não têm referente além do discurso Platão recorre exatamente a elas para precisar sua referência. (shrink)

This paper is concerned with the semantics of bare plural I-generics such as ‘Tigers are striped’, ‘Chickens lay eggs’, and ‘Kangaroos live in Australia’. In a series of recent papers, Bernhard Nickel has developed a comprehensive view of a certain class of bare plural I-generics, which he calls characterizing sentences :629–648, 2009. doi:10.1007/s10988-008-9049-7; Linguist Philos 33:479–512, 2010a. doi:10.1007/s10988-011-9087-4; Philos Impr 10:1–25, 2010b). Nickel’s ambitious proposal includes a detailed account of their truth-conditions, an account of certain pragmatic phenomena that they give (...) rise to, a metaphysical picture of their truth-makers in terms of mechanisms, and an epistemological story connecting characterizing sentences to such concepts as induction and explanation. This paper offers an extended critique of the central truth-conditional component of Nickel’s proposal. In a nutshell, his account has it that ‘Tigers are striped’ is true iff, for tigers, there is a way of being normal with respect to fur-pattern such that all tigers that are normal that way are striped. I begin by explaining what characterizing sentences are and distinguish several readings that are available for sentences with bare plurals in subject position. I then introduce Nickel’s account and discuss some of its predictions which, in my view, seem highly problematic. Moreover, I argue that Nickel’s principle of Homogeneity does not go together well with his proposed truth-conditions, and that his truth-conditional account violates a plausible principle about the logic of generics, a principle I call generic non-contradiction. (shrink)

A paramount, yet unresolved issue in personalised medicine is that of automated reasoning with clinical guidelines in multimorbidity settings. This entails enabling machines to use computerised generic clinical guideline recommendations and patient-specific information to yield patient-tailored recommendations where interactions arising due to multimorbidities are resolved. This problem is further complicated by patient management desiderata, in particular the need to account for patient-centric goals as well as preferences of various parties involved. We propose to solve this problem of automated reasoning with (...) interacting guideline recommendations in the context of a given patient by means of computational argumentation. In particular, we advance a structured argumentation formalism ABA+G (short for Assumption-Based Argumentation with Preferences (ABA+) and Goals) for integrating and reasoning with information about recommendations, interactions, patient’s state, preferences and prioritised goals. ABA+G combines assumption-based reasoning with preferences and goal-driven selection among reasoning outcomes. Specifically, we assume defeasible applicability of guideline recommendations with the general goal of patient well-being, resolve interactions (conflicts and otherwise undesirable situations) among recommendations based on the state and preferences of the patient, and employ patient-centered goals to suggest interaction-resolving, goal-importance maximising and preference-adhering recommendations. We use a well-established Transition-based Medical Recommendation model for representing guideline recommendations and identifying interactions thereof, and map the components in question, together with the given patient’s state, prioritised goals, and preferences over actions, to ABA+G for automated reasoning. In this, we follow principles of patient management and establish corresponding theoretical properties as well as illustrate our approach in realistic personalised clinical reasoning scenaria. (shrink)

In A Virtue Epistemology, Ernest Sosa defines the notions of safety and aptness of beliefs and uses them to characterize two kinds of knowledge, animal and reflective. This paper tries to bring out what I take as an incoherence in Sosa's views concerning how safety and aptness relate to knowledge and to each other. I discuss an apparent counterexample Sosa gives to his final view that aptness suffices for animal knowledge and argue that in fact the principle on which Sosa (...) responds to the counterexample does not permit the response he offers. The principle in question is problematic for Sosa's epistemology in a deeper way: it doesn't seem to cohere with Sosa's view that only aptness, not safety, is required for animal knowledge. En A Virtue Epistemology, Ernesto Sosa define las nociones de seguridad y aptitud de las creencias y las usa para caracterizar dos clases de conocimiento, el animal y el reflexivo. En este artículo discuto lo que parece una incoherencia en las tesis de Sosa acerca de cómo se relacionan la seguridad y la aptitud con el conocimiento y entre sí. Examino un aparente contraejemplo que Sosa plantea a su tesis final de que la aptitud es suficiente para el conocimiento animal, y argumento que el principio que él usa para responder al contraejemplo de hecho no permite dar esa respuesta. El principio en cuestión es problemático para la epistemología de Sosa de una manera más profunda: no parece ser coherente con su tesis central de que sólo la aptitud, no la seguridad, es necesaria para el conocimiento animal. (shrink)

Neglected diseases are severe conditions that mainly affect the world's poorest people. Those suffering from neglected diseases are mostly suffering from tropical infections that have failed to receive priority in pharmaceutical research and development programs, as well as in public health policies aimed at improving availability and access to preventive, diagnostic and curative medicine. The World Health Organization has issued a number of documents directing attention to the plight affecting one third of the world's population, assisted by active support from (...) private organizations, notably the Bill and Melissa Gates Foundation, but the overall situation remains dismal. In the wake of major socioeconomic processes including globalization, steadily growing economic disparity, healthcare inequality, the instability created by rogue states and terrorism, as well as massive migration, and epidemic outbreaks, the features of neglected diseases have been changing. Neglected populations affected by tropical diseases are suffering increasingly from non-infectious degenerative conditions and disabilities due to untreated chronic maladies. Pockets of poverty and neglect can also be detected in high-income countries, contributing to the emergence of new diseases and the reemergence of infections believed to be disappearing such as tuberculosis and the measles. Included in the issues of neglect are rare diseases, mostly of genetic origin, affecting a small number of patients that suffer from multiple life-shortening functional impairment and organ defects. Effective medicines are extremely expensive, allegedly because research and development of appropriate drugs is resources and time consuming, requiring exorbitant prices to recoup investment from a small number of consumers. Bioethics has been tardy in addressing the suffering and destitution of neglected and rare diseases. Convinced that permanently repeated denunciations blunt the sensitivity towards suffering, whereas statistics are bloodless and unable to elicit commitment, this book attempts to explore a different strategy. In an upstream approach, bioethics needs to engage in ethnographic fieldwork that confronts and shares the context in which people suffer, vividly presenting what epidemiological research has blunted into statistical data. Additionally, a downstream approach is suggested, requiring bioethics to vigorously and openly denounce unethical biomedical and pharmaceutical research, misdeeds in registration and marketing of drugs, and misalignment of policies with the unmet healthcare needs of the destitute. More than being critical observers, bioethicists ought to shed lurking conflicts of interests and seek active participation in planning research and public healthcare practices aimed at improving the lives of medically neglected populations. (shrink)

Con ocasión de la refutación de una interpretación reciente del pensamiento de Anthony Collins, fundada en presupuestos metodológicos erráticos y tributarios, en definitiva, de la concepción propia de los apologistas en tiempos de las Luces, este trabajo denuncia los abusos en la historiografía de los tiempos modernos de una mal llamada lectura entre líneas, que implica no el examen detenido del texto en su complejidad, sino el menosprecio de la letra, y propone criterios que faciliten un tratamiento en clave propiamente (...) histórica de categorías como deísmo, panteísmo y ateísmo, lejos de la pretensión de una determinada filosofía de trabajar sobre «conceptos rigurosos y perfectamente definidos», portadores de esencias. (shrink)

Este artículo reconstruye la reflexión de Nietzsche acerca de la condición humana desarrollada a lo largo de su obra central, Así habló Zaratustra. El punto de partida del análisis es el discurso en el mercado situado en el prólogo de la obra, en el que Zaratustra proclama por primera vez el advenimiento del superhombre. La reconstrucción de su posición antropológica supone la consideración de algunos pasajes especialmente relevantes en los que el autor se refiera a la muerte de Dios, al (...) último hombre y el superhombre, la voluntad de poder y el eterno retorno; a manera de conclusión, argumento que, sin perjuicio de la presencia de conceptos como “perspectivismo” o “muerte del sujeto”, la obra no tiene un fin deconstructivo, sino que consiste en una reflexión acerca de la plenitud y la decadencia de la condición humana. (shrink)

It has been traditionally considered that Quantum Mechanics has two conceptual kinds of problems, namely, those related with local-realism and the so-called measurement problem. That is, the uniqueness of the result when we make a measurement. With the development of what is called generically Quantum Information Theory, a new form of the Copenhagen interpretation of the formalism has taken shape.(1) In this paper, we will analyse if this information interpretation is able to clarify these old problems. Although this interpretation seems (...) to be the most promising approach we have, we have reached the conclusion that the answer cannot be given in a positive and clear way yet. (shrink)

LetA≤Bbe structures, and${\cal K}$a class of structures. An elementb∈BisdominatedbyArelative to${\cal K}$if for all${\bf{C}} \in {\cal K}$and all homomorphismsg,g':B → Csuch thatgandg'agree onA, we havegb=g'b. Our main theorem states that if${\cal K}$is closed under ultraproducts, thenAdominatesbrelative to${\cal K}$if and only if there is a partial functionFdefinable by a primitive positive formula in${\cal K}$such thatFB(a1,…,an) =bfor somea1,…,an∈A. Applying this result we show that a quasivariety of algebras${\cal Q}$with ann-ary near-unanimity term has surjective epimorphisms if and only if$\mathbb{S}\mathbb{P}_n \mathbb{P}_u \left( {\mathcal{Q}_{{\text{RSI}}} } \right)$has (...) surjective epimorphisms. It follows that if${\cal F}$is a finite set of finite algebras with a common near-unanimity term, then it is decidable whether the (quasi)variety generated by${\cal F}$has surjective epimorphisms. (shrink)